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CD2AP an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Required for cytokinesis. Links CD2 engagement to the WASp-evoked actin polymerization required for synapse formation and T cell activation. Attaches to membrane proteins via its three SH3 domains and attaches to and rearranges the cytoskeleton via its C-terminus. CD2AP?s interactions with the cytoskeleton result in receptor clustering and endocysosis as well as targeting proteins to degradative vesicles in the kidney. Mice carrying a heterozygous knockout of CD2AP show defects in kidney filtration, and mutations in the human gene are associated with focal segmental glomerulosclerosis (FSGS3). Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 6p12.3
Cellular Component: actin cytoskeleton; cytoplasm; filamentous actin; ruffle
Molecular Function: cadherin binding; protein binding; SH3 domain binding; structural constituent of cytoskeleton
Biological Process: protein complex assembly; substrate-bound cell migration, cell extension
Disease: Focal Segmental Glomerulosclerosis 3, Susceptibility To
Reference #:  Q9Y5K6 (UniProtKB)
Alt. Names/Synonyms: Adapter protein CMS; Cas ligand with multiple SH3 domains; Cas ligand with multiple Src homology 3 (SH3) domains; CD2-associated protein; CD2AP; CMS; DKFZp586H0519
Gene Symbols: CD2AP
Molecular weight: 71,451 Da
Basal Isoelectric point: 6.07  Predict pI for various phosphorylation states
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