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ANXA2 a calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. Heterotetramer containing 2 light chains of S100A10 2 heavy chains of ANXA2. May cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding; Lipid-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 15q22.2
Cellular Component: basolateral plasma membrane; cell surface; cell-cell adherens junction; cytoplasm; endosome; extracellular matrix; extracellular region; extracellular space; late endosome membrane; lipid particle; lipid raft; lysosomal membrane; membrane; midbody; nucleus; plasma membrane; vesicle
Molecular Function: calcium-dependent phospholipid binding; calcium-dependent protein binding; identical protein binding; phosphatidylinositol-4,5-bisphosphate binding; phospholipase A2 inhibitor activity; protease binding; protein binding; receptor activator activity; RNA binding
Biological Process: angiogenesis; catabolism by host of symbiont protein; lipid raft formation; membrane budding; negative regulation by host of symbiont molecular function; negative regulation of low-density lipoprotein receptor catabolic process; neutrophil degranulation; positive regulation of receptor recycling; positive regulation of vesicle fusion; protein heterotetramerization
Reference #:  P07355 (UniProtKB)
Alt. Names/Synonyms: Annexin A2; Annexin II; Annexin-2; ANX2; ANX2L4; anxa 2; ANXA2; CAL1H; Calpactin I heavy chain; calpactin I heavy polypeptide; Calpactin-1 heavy chain; chromobindin 8; Chromobindin-8; LIP2; Lipocortin II; LPC2; LPC2D; p36; PAP-IV; Placental anticoagulant protein IV; Protein I
Gene Symbols: ANXA2
Molecular weight: 38,604 Da
Basal Isoelectric point: 7.57  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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