a member of the ubiquitin family of proteins. Approximately 60% identical to ubiquitin protein.. Activated by an E1-like complex, consisting of App-b1 and Uba3 and then linked to the E2-like enzyme, Ubc12. The major target protein modified by nedd8 is cullin-4a. Down-regulated during the development of brain. Note: This description may include information from UniProtKB.
Molecular Function: protein binding; ubiquitin protein ligase binding
Biological Process: anatomical structure morphogenesis; cellular iron ion homeostasis; cellular protein modification process; post-translational protein modification; protein deubiquitination; protein localization; protein neddylation; protein ubiquitination; proteolysis; regulation of transcription from RNA polymerase II promoter; response to organic cyclic compound; transforming growth factor beta receptor signaling pathway; ubiquitin-dependent protein catabolic process