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NEDD8 a member of the ubiquitin family of proteins. Approximately 60% identical to ubiquitin protein.. Activated by an E1-like complex, consisting of App-b1 and Uba3 and then linked to the E2-like enzyme, Ubc12. The major target protein modified by nedd8 is cullin-4a. Down-regulated during the development of brain. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin-like modifier
Chromosomal Location of Human Ortholog: 14q12
Cellular Component: cytosol; extracellular exosome; nucleoplasm; nucleus
Molecular Function: protein binding; ubiquitin protein ligase binding
Biological Process: anatomical structure morphogenesis; cellular iron ion homeostasis; cellular protein modification process; post-translational protein modification; protein deubiquitination; protein localization; protein neddylation; protein ubiquitination; proteolysis; regulation of transcription from RNA polymerase II promoter; response to organic cyclic compound; transforming growth factor beta receptor signaling pathway; ubiquitin-dependent protein catabolic process
Reference #:  Q15843 (UniProtKB)
Alt. Names/Synonyms: FLJ43224; MGC104393; MGC125896; MGC125897; NEDD-8; NEDD8; Neddylin; Neural precursor cell expressed developmentally down-regulated protein 8; neural precursor cell expressed, developmentally down-regulated 8; Ubiquitin-like protein Nedd8
Gene Symbols: NEDD8
Molecular weight: 9,072 Da
Basal Isoelectric point: 7.99  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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