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SLAP-130 an adapter protein for fyn and the SH2-domain-containing leucocyte protein-76 (SLP76) in T cells. T-cell receptor ligation leads to increased tyrosine phosphorylation of SLAP-130. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 5p13.1
Cellular Component: actin cytoskeleton; cytosol; plasma membrane
Molecular Function: protein binding; receptor binding
Biological Process: NLS-bearing substrate import into nucleus; protein amino acid phosphorylation; signal transduction; T cell receptor signaling pathway
Disease: Thrombocytopenia 3
Reference #:  O15117 (UniProtKB)
Alt. Names/Synonyms: ADAP; Adhesion and degranulation promoting adaptor protein; adhesion and degranulation-promoting adaptor protein; FYB; FYB-120/130; FYN binding protein (FYB-120/130); FYN-binding protein; FYN-binding protein (FYB-120/130); FYN-T-binding protein; p120/p130; PRO0823; SLAP-130; SLAP130; SLP-76-associated phosphoprotein
Gene Symbols: FYB
Molecular weight: 85,387 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
CST Pathways:  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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