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SKIL May have regulatory role in cell division or differentiation in response to extracellular signals. Interacts with SMAD2, SMAD3 and RNF111. Isoform 1 interacts with WWP1. Isoform SNON and isoform SNOA are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Isoform SNOI expression is restricted to skeletal muscle. Belongs to the SKI family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 3q26.2
Cellular Component: nucleoplasm; protein complex
Molecular Function: protein binding; SMAD binding
Biological Process: negative regulation of BMP signaling pathway; negative regulation of cell differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; neuron development
Reference #:  P12757 (UniProtKB)
Alt. Names/Synonyms: SKI-like oncogene; Ski-like protein; Ski-related oncogene; ski-related oncogene snoN; Ski-related protein; SKIL; SNO; SnoA; SnoI; SnoN
Gene Symbols: SKIL
Molecular weight: 76,976 Da
Basal Isoelectric point: 6.72  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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