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USP10 a carboxyl-terminal ubiquitin-processing protease. Ras-GAP SH3 domain-binding protein (G3BP) appears to inhibit its ability to disassemble ubiquitin chains. Note: This description may include information from UniProtKB.
Protein type: EC; Protease; RNA-binding; Ubiquitin conjugating system; Ubiquitin-specific protease
Chromosomal Location of Human Ortholog: 16q24.1
Cellular Component: cytoplasm; cytosol; early endosome; nucleoplasm; nucleus; protein complex
Molecular Function: cysteine-type endopeptidase activity; p53 binding; protein binding; RNA binding; ubiquitin-specific protease activity
Biological Process: bypass DNA synthesis; DNA damage response, signal transduction by p53 class mediator; negative regulation of I-kappaB kinase/NF-kappaB cascade; protein deubiquitination; regulation of autophagy; response to DNA damage stimulus
Reference #:  Q14694 (UniProtKB)
Alt. Names/Synonyms: Deubiquitinating enzyme 10; KIAA0190; MGC2621; Ubiquitin carboxyl-terminal hydrolase 10; ubiquitin specific peptidase 10; ubiquitin specific protease 10; Ubiquitin thioesterase 10; Ubiquitin-specific-processing protease 10; UBP10; UBPO; USP10
Gene Symbols: USP10
Molecular weight: 87,134 Da
Basal Isoelectric point: 5.19  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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