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Pnk1 polynucleotide kinase 3'-phosphatase. May be involved in double-strand break repair by non-homologous end joining. Required for normal response to DNA damage by gamma-radiation or camptothecin in S. pombe. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; EC; EC; Kinase, other; Phosphatase (non-protein)
Chromosomal Location of Human Ortholog: 19q13.33
Cellular Component: membrane; nucleolus; nucleoplasm; nucleus
Molecular Function: ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity; double-stranded DNA binding; nucleotide kinase activity; polynucleotide 3'-phosphatase activity; protein binding
Biological Process: dephosphorylation; DNA damage response, detection of DNA damage; DNA repair; nucleotide phosphorylation; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; response to oxidative stress; response to radiation
Disease: Ataxia-oculomotor Apraxia 4; Microcephaly, Seizures, And Developmental Delay
Reference #:  Q96T60 (UniProtKB)
Alt. Names/Synonyms: 2'(3')-polynucleotidase; Bifunctional polynucleotide phosphatase/kinase; DNA 5'-kinase/3'-phosphatase; Homo sapiens polynucleotide kinase 3'-phosphatase (PNKP); PNK; PNKP; Polynucleotide 3'-phosphatase; Polynucleotide 5'-hydroxyl-kinase; polynucleotide kinase 3'-phosphatase; polynucleotide kinase 3-prime-phosphatase; Polynucleotide kinase-3'-phosphatase
Gene Symbols: PNKP
Molecular weight: 57,076 Da
Basal Isoelectric point: 8.73  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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