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CHD-4 is an ATP-dependent helicase and a central component of the HDAC-containing nucleosome remodeling and histone deacetylase (NuRD) transcriptional complex. Interacts with MTA1/2, HDAC1, and RbAp46 in the NuRD complex. CHD-4 belongs to the SNF2/RAD54 helicase family of proteins. The NuRD complex, whose subunit composition varies by cell type and in response to physiologic signals, plays central roles in many processes including oncogenesis and metastasis, B cell differentiation, invasive growth of breast cancer, and maintaining the balance between the undifferentiated state and the process of differentiation in embryonic stem cells. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; EC; Helicase
Chromosomal Location of Human Ortholog: 12p13.31
Cellular Component: centrosome; cytoplasm; membrane; nuclear chromatin; nucleoplasm; nucleus; NuRD complex; protein complex
Molecular Function: ATP-dependent DNA helicase activity; DNA binding; histone deacetylase activity; histone deacetylase binding; nucleosomal DNA binding; protein binding; zinc ion binding
Biological Process: ATP-dependent chromatin remodeling; regulation of transcription from RNA polymerase II promoter
Disease: Sifrim-hitz-weiss Syndrome
Reference #:  Q14839 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent helicase CHD4; CHD-4; CHD4; chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4; DKFZp686E06161; Mi-2 autoantigen 218 kDa protein; Mi-2b; Mi2-beta
Gene Symbols: CHD4
Molecular weight: 218,005 Da
Basal Isoelectric point: 5.62  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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