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VTI1A V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non- conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence. Belongs to the VTI1 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 10q25.2
Cellular Component: autophagic vacuole; cell soma; clathrin-coated vesicle; endoplasmic reticulum membrane; endosome; Golgi apparatus; Golgi membrane; intracellular membrane-bound organelle; late endosome membrane; perinuclear region of cytoplasm; SNARE complex; synaptic vesicle; trans-Golgi network membrane
Molecular Function: protein binding; SNAP receptor activity; SNARE binding
Biological Process: autophagy; ER to Golgi vesicle-mediated transport; Golgi to vacuole transport; intra-Golgi vesicle-mediated transport; protein targeting to vacuole; retrograde transport, endosome to Golgi; vesicle fusion with Golgi apparatus; voluntary musculoskeletal movement
Disease: Multiple Mitochondrial Dysfunctions Syndrome 3
Reference #:  Q96AJ9 (UniProtKB)
Alt. Names/Synonyms: MVti1; SNARE Vti1a-beta protein; Vesicle transport through interaction with t-SNAREs homolog 1A; vesicle transport through interaction with t-SNAREs homolog 1A (yeast); Vesicle transport v-SNARE protein Vti1-like 2; Vti1-rp2; VTI1A
Gene Symbols: VTI1A
Molecular weight: 25,218 Da
Basal Isoelectric point: 6.06  Predict pI for various phosphorylation states
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