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MCM2 a mini-chromosome maintenance protein, essential for the initiation of eukaryotic genome replication. Allows DNA to undergo a single round of replication per cell cycle. Required for the entry in S phase and for cell division. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; EC
Chromosomal Location of Human Ortholog: 3q21.3
Cellular Component: chromatin; cytoplasm; cytosol; MCM complex; microtubule cytoskeleton; nuclear chromosome, telomeric region; nucleolus; nucleoplasm; nucleus
Molecular Function: DNA binding; protein binding
Biological Process: apoptosis; DNA replication; DNA replication initiation; G1/S transition of mitotic cell cycle
Disease: Deafness, Autosomal Dominant 70
Reference #:  P49736 (UniProtKB)
Alt. Names/Synonyms: BM28; CCNL1; cdc19; CDCL1; cell devision cycle-like 1; cyclin-like 1; D3S3194; DNA replication licensing factor MCM2; KIAA0030; MCM2; MCM2 minichromosome maintenance deficient 2, mitotin; MGC10606; minichromosome maintenance complex component 2; minichromosome maintenance deficient 2 (mitotin); Minichromosome maintenance protein 2 homolog; MITOTIN; Nuclear protein BM28
Gene Symbols: MCM2
Molecular weight: 101,896 Da
Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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