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APPL an effector protein of the small GTPase Rab5, a key regulator of endocytosis. Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction. Contains a PH domain and an N-terminal PID domain. Its interaction with RAB5A/Rab5 is essential for its recruitment to endosomal membranes as well as its role in cell proliferation. Binds DCC and the catalytic domain of the inactive form of AKT2 through its PID domain. Binds PIK3CA and subunits of the NuRD/MeCP1 complex. Phosphorylated upon DNA damage. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 3p14.3
Cellular Component: cytoplasm; cytosol; early endosome; endosome membrane; nucleus; NuRD complex; vesicle membrane
Molecular Function: identical protein binding; protein binding; protein kinase B binding
Biological Process: cell proliferation; insulin receptor signaling pathway; regulation of glucose import; signal transduction
Disease: Maturity-onset Diabetes Of The Young, Type 14
Reference #:  Q9UKG1 (UniProtKB)
Alt. Names/Synonyms: Adapter protein containing PH domain, PTB domain and leucine zipper motif 1; adaptor protein containing pH domain, PTB domain and leucine zipper motif 1; adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; AKT2 interactor; APPL; APPL1; DCC-interacting protein 13-alpha; Dip13-alpha; DIP13A; DIP13alpha; DP13A; KIAA1428; signaling adaptor protein DIP13alpha
Gene Symbols: APPL1
Molecular weight: 79,663 Da
Basal Isoelectric point: 5.28  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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