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XPC a probable nuclear protein involved in DNA excision repair. May play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes. Defects in XPC are a cause of xeroderma pigmentosum complementation group C. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage
Chromosomal Location of Human Ortholog: 3p25.1
Cellular Component: cytoplasm; intracellular membrane-bound organelle; mitochondrion; nucleolus; nucleoplasm; nucleus; plasma membrane
Molecular Function: bubble DNA binding; damaged DNA binding; loop DNA binding; protein binding; single-stranded DNA binding
Biological Process: DNA repair; mismatch repair; nucleotide-excision repair; nucleotide-excision repair, DNA damage recognition; nucleotide-excision repair, DNA duplex unwinding; nucleotide-excision repair, preincision complex assembly
Disease: Xeroderma Pigmentosum, Complementation Group C
Reference #:  Q01831 (UniProtKB)
Alt. Names/Synonyms: DNA repair protein complementing XP-C cells; p125; RAD4; Xeroderma pigmentosum group C-complementing protein; xeroderma pigmentosum, complementation group C; XP3; XPC; XPCC
Gene Symbols: XPC
Molecular weight: 105,953 Da
Basal Isoelectric point: 9.03  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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