Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

Scribble may be involved in regulating neuroblast cortical polarity, cell size asymmetry and mitotic spindle asymmetry. A neoplastic tumor suppressor genes in Drosophila melanogaster. May play a role in the suppression of mammalian tumorigenesis. Gene ablation in the mouse causes severe neural tube defects. May be implicated in the etiology of human NTDs. Involved in the regulation of synaptic plasticity and synaptic vesicle dynamics. May be required to sustain synaptic vesicle concentrations at their sites of release. Targeted for ubiquitin-mediated degradation by the HPV E6 oncoprotein. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 8q24.3
Cellular Component: basolateral plasma membrane; cell junction; cell-cell adherens junction; intercellular junction; ionotropic glutamate receptor complex; leading edge; nucleoplasm; plasma membrane; postsynaptic density; postsynaptic membrane; presynaptic membrane
Molecular Function: cadherin binding; guanylate kinase activity; ionotropic glutamate receptor binding; protein binding
Biological Process: cell migration; cell proliferation; cell-cell adhesion; establishment and/or maintenance of epithelial cell polarity; establishment of apical/basal cell polarity; negative regulation of mitotic cell cycle; neural tube closure; positive chemotaxis; positive regulation of apoptosis; positive regulation of receptor recycling; receptor clustering; synaptic transmission
Reference #:  Q14160 (UniProtKB)
Alt. Names/Synonyms: CRIB1; hScrib; KIAA0147; LAP4; Protein LAP4; Protein scribble homolog; SCRB1; SCRIB; SCRIB1; Scribble; scribbled homolog (Drosophila); VARTUL
Gene Symbols: SCRIB
Molecular weight: 174,885 Da
Basal Isoelectric point: 5.01  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene