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RAD18 a structural maintenance of chromosomes (SMC) protein involved in postreplication repair of UV-damaged DNA. Has ssDNA binding activity. Interacts with Rad6 through a conserved ring-finger motif. Rad6 is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; EC 6.3.2.-; EC; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 3p25.3
Cellular Component: centrosome; nuclear body; nuclear inclusion body; nucleoplasm; nucleus; replication fork
Molecular Function: identical protein binding; polyubiquitin binding; protein binding; protein complex binding; single-stranded DNA-dependent ATPase activity; ubiquitin protein ligase binding; Y-form DNA binding
Biological Process: DNA damage response, detection of DNA damage; positive regulation of chromosome segregation; postreplication repair; protein autoubiquitination; protein monoubiquitination; protein ubiquitination; response to DNA damage stimulus; response to UV
Reference #:  Q9NS91 (UniProtKB)
Alt. Names/Synonyms: E3 ubiquitin-protein ligase RAD18; hHR18; hRAD18; postreplication repair protein hRAD18p; Postreplication repair protein RAD18; RAD18; RAD18 homolog (S. cerevisiae); RAD18, S. cerevisiae, homolog; RING finger protein 73; RNF73
Gene Symbols: RAD18
Molecular weight: 56,223 Da
Basal Isoelectric point: 7.51  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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