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MTA1 metastasis-associated protein. A component of the NuRD ATP-dependent chromatin remodeling and histone deacetylase complex. Interacts with HDAC1. Expressed at high levels in metastatic cells. Two alternatively spliced isoforms have been described. The long isoform is a co-repressor of estrogen receptor (ER). The short isoform binds to ER and sequesters it in the cytoplasm and enhances non-genomic responses of ER. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 14q32.33
Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; microtubule; nuclear envelope; nucleoplasm; nucleus
Molecular Function: histone deacetylase activity; protein binding; transcription coactivator activity; transcription corepressor activity
Biological Process: circadian regulation of gene expression; double-strand break repair; entrainment of circadian clock by photoperiod; locomotor rhythm; proteasomal ubiquitin-dependent protein catabolic process; protein sumoylation; regulation of gene expression, epigenetic; regulation of inflammatory response; response to ionizing radiation; response to lipopolysaccharide; signal transduction
Reference #:  Q13330 (UniProtKB)
Alt. Names/Synonyms: metastasis associated 1; metastasis associated gene 1 protein; metastasis associated protein; Metastasis-associated protein MTA1; MTA1
Gene Symbols: MTA1
Molecular weight: 80,786 Da
Basal Isoelectric point: 9.34  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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