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CISH SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate- recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Stably associated with the tyrosine-phosphorylated IL3 receptor beta chain and tyrosine-phosphorylated EPO receptor (EPOR). By a subset of cytokines including EPO/erythropoietin. Expressed in various epithelial tissues. Abundantly expressed in liver and kidney, and to a lesser extent in lung. The tissue distribution of isoforms 1 and 1B is distinct. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 3p21.2
Cellular Component: cytoplasm; cytosol
Molecular Function: protein binding; protein kinase inhibitor activity
Biological Process: cytokine and chemokine mediated signaling pathway; negative regulation of insulin receptor signaling pathway; negative regulation of JAK-STAT cascade; negative regulation of protein kinase activity; post-translational protein modification
Disease: Bacteremia, Susceptibility To, 2; Malaria, Susceptibility To; Mycobacterium Tuberculosis, Susceptibility To
Reference #:  Q9NSE2 (UniProtKB)
Alt. Names/Synonyms: CIS; CIS-1; CISH; cytokine inducible SH2-containing protein; cytokine-inducible inhibitor of signaling type 1B; Cytokine-inducible SH2-containing protein; G18; Protein G18; SOCS; Suppressor of cytokine signaling
Gene Symbols: CISH
Molecular weight: 28,663 Da
Basal Isoelectric point: 6.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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