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EIF4G2 a general repressor of translation by forming translationally inactive complexes. Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Interacts with the protein kinases Mnk1 and -2. Binds EIF4A and EIF3. Cleaved by some caspases and viral proteases. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Translation; Translation initiation
Chromosomal Location of Human Ortholog: 11p15.4
Cellular Component: cell-cell adherens junction; cytosol; eukaryotic translation initiation factor 4F complex; membrane
Molecular Function: cadherin binding; protein binding; RNA binding; translation factor activity, nucleic acid binding; translation initiation factor activity
Biological Process: cell cycle arrest; cell death; negative regulation of autophagy; positive regulation of cell growth; regulation of translational initiation
Reference #:  P78344 (UniProtKB)
Alt. Names/Synonyms: AAG1; aging-associated protein 1; DAP-5; DAP5; Death-associated protein 5; eIF-4-gamma 2; eIF-4G 2; eIF4G 2; EIF4G2; Eukaryotic translation initiation factor 4 gamma 2; eukaryotic translation initiation factor 4 gamma, 2; eukaryotic translation initiation factor 4G-like 1; FLJ41344; IF4G2; NAT1; p97
Gene Symbols: EIF4G2
Molecular weight: 102,362 Da
Basal Isoelectric point: 6.7  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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