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CDT1 an essential licensing protein for DNA replication. Cooperates with CDC6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to form the pre-replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Elevated in all human tumor cell lines analyzed. May function as an oncogene in mammals. Interaction with GMNN inhibits both binding of the MCM complex to origins of replication and DNA-binding activity. Present during G1 and early S phase of the cell cycle. Degraded during the late S, G2, and M phases. Note: This description may include information from UniProtKB.
Protein type: DNA replication; DNA-binding; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of Human Ortholog: 16q24.3
Cellular Component: cytoplasm; cytosol; kinetochore; nuclear body; nucleoplasm; nucleus
Molecular Function: chromatin binding; DNA binding; protein binding
Biological Process: attachment of spindle microtubules to kinetochore during mitosis; cell division; chromosome segregation; DNA replication checkpoint; G1/S transition of mitotic cell cycle; G1/S-specific transcription in mitotic cell cycle; kinetochore organization and biogenesis; mitotic cell cycle; positive regulation of protein complex assembly; regulation of chromosome organization and biogenesis; regulation of DNA replication initiation
Disease: Meier-gorlin Syndrome 4
Reference #:  Q9H211 (UniProtKB)
Alt. Names/Synonyms: CDT1; chromatin licensing and DNA replication factor 1; DNA replication factor Cdt1; Double parked homolog; Double parked, Drosophila, homolog of; DUP; RIS2
Gene Symbols: CDT1
Molecular weight: 60,390 Da
Basal Isoelectric point: 9.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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