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BCR-ABL1 an oncogenic fusion protein between the tyrosine kinase Abl and the BCR (breakpoint cluster region) protein. Results from a translocation between chromosome 9 and 22 t(9;22)(q34;q11), or the Philadelphia translocation (Ph). Found in 95% of people with chronic myelogenous leukemia (CML), 25-30% of adult cases and 2¿10% of pediatric cases of acute lymphoblastic leukemia (ALL), and occasionally in acute myelogenous leukemia (AML). Multiple isoforms resulting from varying locations of the BCR breakpoint have been reported. Three clinically important variants are the p190, p210 and p230 isoforms. p190 is generally associated with ALL, while p210 is generally associated with CML but can also be associated with ALL. p230 is usually associated with CML. The longest isoform is shown here. Note: This description may include information from UniProtKB.
Protein type: Abl family; EC; Fusion protein; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group
Reference #:  A9UF07 (UniProtKB)
Alt. Names/Synonyms: Abl; Abl1; ALL; BCR; BCR/ABL; BCR/ABL fusion protein isoform Y5; BCR1; breakpoint cluster region; CML; D22S11; D22S662; FLJ16453; PHL; renal carcinoma antigen NY-REN-26
Gene Symbols: BCR/ABL
Molecular weight: 196,572 Da
Basal Isoelectric point: 8.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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