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NT5E Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Homodimer; disulfide-linked. Belongs to the 5'-nucleotidase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC; Membrane protein, GPI anchor; Membrane protein, integral; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Phosphatase (non-protein)
Chromosomal Location of Human Ortholog: 6q14.3
Cellular Component: cell surface; cytosol; membrane; plasma membrane
Molecular Function: 5'-nucleotidase activity
Biological Process: DNA metabolic process; leukocyte adhesion; NAD metabolic process; purine nucleotide catabolic process; pyrimidine nucleoside catabolic process
Disease: Calcification Of Joints And Arteries
Reference #:  P21589 (UniProtKB)
Alt. Names/Synonyms: 5' nucleotidase (CD73); 5'-NT; 5'-nucleotidase; 5'-nucleotidase, ecto (CD73); 5NTD; CD73; E5NT; Ecto-5'-nucleotidase; eN; eNT; NT; NT5; NT5E; NTE; Purine 5-Prime-Nucleotidase
Gene Symbols: NT5E
Molecular weight: 63,368 Da
Basal Isoelectric point: 6.58  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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