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NR6A1 Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis. Homodimer. Interacts with UIMC1. Shows highest expression in the germ cells of the adult testis. Belongs to the nuclear hormone receptor family. NR6 subfamily. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor
Chromosomal Location of Human Ortholog: 9q33.3
Cellular Component: nucleoplasm; nucleus; transcription factor complex
Molecular Function: DNA binding; ligand-dependent nuclear receptor activity; protein homodimerization activity; sequence-specific DNA binding
Biological Process: cell proliferation; gamete generation; negative regulation of transcription from RNA polymerase II promoter; spermatogenesis; steroid hormone receptor signaling pathway; transcription initiation from RNA polymerase II promoter
Reference #:  Q15406 (UniProtKB)
Alt. Names/Synonyms: GCNF; GCNF1; Germ cell nuclear factor; hGCNF; hRTR; NR61; NR6A1; Nuclear receptor subfamily 6 group A member 1; nuclear receptor subfamily 6, group A, member 1; retinoic acid receptor-related testis-associated receptor; Retinoid receptor-related testis-specific receptor; RTR
Gene Symbols: NR6A1
Molecular weight: 54,383 Da
Basal Isoelectric point: 5.87  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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