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MYO6 a molecular motor involved in intracellular vesicle and organelle transport. It is one of the so-called unconventional myosins. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 6q14.1
Cellular Component: cell cortex; clathrin-coated endocytic vesicle; cytoplasm; cytoplasmic vesicle; cytosol; DNA-directed RNA polymerase II, holoenzyme; endocytic vesicle; filamentous actin; Golgi apparatus; lysosomal membrane; membrane; nuclear membrane; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; ruffle; unconventional myosin complex
Molecular Function: actin binding; actin filament binding; ADP binding; cadherin binding; calmodulin binding; motor activity; protein binding
Biological Process: actin filament-based movement; DNA damage response, signal transduction by p53 class mediator; endocytosis; intracellular protein transport; positive regulation of transcription from RNA polymerase II promoter; regulation of secretion
Disease: Deafness, Autosomal Dominant 22; Deafness, Autosomal Recessive 37
Reference #:  Q9UM54 (UniProtKB)
Alt. Names/Synonyms: DFNA22; DFNB37; KIAA0389; MYO6; myosin VI; Myosin-VI; Unconventional myosin-6
Gene Symbols: MYO6
Molecular weight: 149,691 Da
Basal Isoelectric point: 8.74  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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