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ATP1A1 the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na and K ions across the plasma membrane. This action creates the electrochemical gradient of Na and K, providing the energy for active transport of various nutrients. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of Human Ortholog: 2q34
Cellular Component: apical plasma membrane; basolateral plasma membrane; caveola; endoplasmic reticulum; endosome; Golgi apparatus; integral to membrane; lipid raft; membrane; myelin sheath; plasma membrane; postsynaptic density; protein complex; sarcolemma; sodium:potassium-exchanging ATPase complex; T-tubule
Molecular Function: ADP binding; ankyrin binding; ATP binding; chaperone binding; phosphoinositide 3-kinase binding; phosphoric monoester hydrolase activity; potassium ion binding; protein binding; protein domain specific binding; protein kinase binding; sodium ion binding; sodium:potassium-exchanging ATPase activity
Biological Process: cardiac muscle contraction; cellular potassium ion homeostasis; cellular sodium ion homeostasis; energy coupled proton transport, against electrochemical gradient; establishment and/or maintenance of transmembrane electrochemical gradient; membrane hyperpolarization; negative regulation of glucocorticoid biosynthetic process; negative regulation of heart contraction; positive regulation of heart contraction; positive regulation of striated muscle contraction; potassium ion import; potassium ion transport; regulation of blood pressure; regulation of sodium ion transport; regulation of the force of heart contraction; response to drug; sodium ion transport
Reference #:  P06685 (UniProtKB)
Alt. Names/Synonyms: AT1A1; Atp1a1; ATPase, Na+/K+ transporting, alpha 1 polypeptide; ATPase, Na+K+ transporting, alpha 1; Na(+)/K(+) ATPase alpha-1 subunit; Nkaa1b; Sodium pump subunit alpha-1; Sodium/potassium-transporting ATPase subunit alpha-1
Gene Symbols: Atp1a1
Molecular weight: 113,054 Da
Basal Isoelectric point: 5.3  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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