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BIM a pro-apoptotic member of the BCL-2 protein family. Interacts with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and act as an apoptotic activator. Its expression can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role in neuronal and lymphocyte apoptosis. Transgenic studies in the mouse suggested that this protein functions as an essential initiator of the apoptosis in thymocyte-negative selection. Nineteen alternatively spliced transcript variants of this gene have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 2|2 F1
Cellular Component: cytoplasm; cytoplasmic dynein complex; cytosol; extrinsic to membrane; intracellular membrane-bound organelle; microtubule; mitochondrion
Molecular Function: microtubule binding; protein binding; protein heterodimerization activity
Biological Process: B cell apoptosis; B cell homeostasis; caspase activation; cell-matrix adhesion; cellular process regulating host cell cycle in response to virus; DNA damage response, signal transduction resulting in induction of apoptosis; ear development; in utero embryonic development; kidney development; leukocyte homeostasis; lumen formation; lymphocyte homeostasis; male gonad development; mammary gland development; myeloid cell homeostasis; odontogenesis of dentine-containing teeth; pigmentation during development; positive regulation of apoptosis; positive regulation of apoptosis by virus; positive regulation of caspase activity; positive regulation of cell cycle; positive regulation of neuron apoptosis; positive regulation of protein homooligomerization; post-embryonic development; post-embryonic organ morphogenesis; regulation of apoptosis; regulation of organ growth; regulation of pigmentation during development; spermatogenesis; spleen development; T cell homeostasis; thymus development
Reference #:  O54918 (UniProtKB)
Alt. Names/Synonyms: 1500006F24Rik; B2L11; Bcl-2-like protein 11; Bcl2 interacting mediator of cell death; Bcl2-interacting mediator of cell death; Bcl2-L-11; BCL2-like 11 (apoptosis facilitator); Bcl2l11; Bim; Bod; OTTMUSP00000016362; OTTMUSP00000016364; OTTMUSP00000016365; RP23-134I15.1
Gene Symbols: Bcl2l11
Molecular weight: 22,067 Da
Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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