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uPAR Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. Expressed in neurons of the rolandic area of the brain. Expressed in the brain. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, GPI anchor; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 19q13.31
Cellular Component: cell surface; endoplasmic reticulum lumen; endoplasmic reticulum membrane; extrinsic to membrane; focal adhesion; plasma membrane
Molecular Function: enzyme binding; protein binding; protein domain specific binding; receptor binding; U-plasminogen activator receptor activity
Biological Process: attachment of GPI anchor to protein; chemotaxis; fibrinolysis; negative regulation of apoptosis; neutrophil degranulation; positive regulation of DNA binding; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of protein amino acid phosphorylation; signal transduction
Reference #:  Q03405 (UniProtKB)
Alt. Names/Synonyms: CD87; MO3; Monocyte activation antigen Mo3; plasminogen activator, urokinase receptor; PLAUR; U-PAR; u-plasminogen activator receptor form 2; UPAR; URKR; Urokinase plasminogen activator surface receptor
Gene Symbols: PLAUR
Molecular weight: 36,978 Da
Basal Isoelectric point: 6.19  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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