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SRC-1 a transcriptional coactivator for steroid and nuclear hormone receptors. A member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, and bHLH and PAS domains. Phosphorylated and activated via the mitogen-activated protein kinase pathway. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; DNA-binding; EC; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 2p23.3
Cellular Component: cytosol; nuclear chromatin; nucleoplasm; plasma membrane; protein complex
Molecular Function: aryl hydrocarbon receptor binding; enzyme binding; estrogen receptor binding; ligand-dependent nuclear receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; protein binding; protein N-terminus binding; transcription coactivator activity
Biological Process: bile acid and bile salt transport; cellular response to hormone stimulus; intracellular receptor-mediated signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter by galactose; positive regulation of transcription, DNA-dependent; regulation of lipid metabolic process; transcription, DNA-dependent
Reference #:  Q15788 (UniProtKB)
Alt. Names/Synonyms: bHLHe42; BHLHE74; Class E basic helix-loop-helix protein 74; F-SRC-1; Hin-2 protein; KAT13A; MGC129719; MGC129720; NCoA-1; NCOA1; Nuclear receptor coactivator 1; PAX3/NCOA1 fusion protein; Protein Hin-2; Renal carcinoma antigen NY-REN-52; RIP160; SRC-1; SRC1; Steroid receptor coactivator 1; steroid receptor coactivator-1
Gene Symbols: NCOA1
Molecular weight: 156,757 Da
Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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