Protein Mutation Frequency in Cancer
The 'lollipop plot' above illustrates recurrent (observed in 3 or more out of 4440 TCGA tumor samples from 15 cancer types) and therefore potentially oncogenic missense mutations (click on 'Show Cancer Mutations').
The bar plot below shows the proportion of tumor samples that have any kind of altering mutation(s) in the given protein.
Learn more about the integration of cancer data in PhosphoSitePlus:
We integrated 4440 tumor samples from 15 cancer types from TCGA (The Cancer Genome Atlas).
To retrieve more detailed mutation information, we recommend cBioPortal.
We integrated the following cancer types:
| • Acute Myeloid Leukemia (TCGA, NEJM 2013) |
| • Bladder Urothelial Carcinoma (TCGA, Nature 2014) |
| • Breast Invasive Carcinoma (TCGA, Cell 2015) |
| • Colorectal Adenocarcinoma (TCGA, Nature 2012) |
| • Glioblastoma (TCGA, Cell 2013) |
| • Head and Neck Squamous Cell Carcinoma (TCGA, Nature 2015) |
| • Kidney Chromophobe (TCGA, Cancer Cell 2014) |
| • Kidney Renal Clear Cell Carcinoma (TCGA, Nature 2013) |
| • Lung Adenocarcinoma (TCGA, Nature 2014) |
| • Lung Squamous Cell Carcinoma (TCGA, Nature 2012) |
| • Ovarian Serous Cystadenocarcinoma (TCGA, Nature 2011) |
| • Papillary Thyroid Carcinoma (TCGA, Cell 2014) |
| • Prostate Adenocarcinoma (TCGA, Cell 2015) |
| • Stomach Adenocarcinoma (TCGA, Nature 2014) |
| • Uterine Corpus Endometrial Carcinoma (TCGA, Nature 2013) |
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