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TNNT2 Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. Belongs to the troponin T family. 11 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component: cytosol; sarcomere; striated muscle thin filament; troponin complex
Molecular Function: actin binding; protein binding; tropomyosin binding; troponin C binding; troponin I binding
Biological Process: cardiac muscle contraction; muscle filament sliding; negative regulation of ATPase activity; positive regulation of ATPase activity; regulation of heart contraction; response to calcium ion; ventricular cardiac muscle morphogenesis
Disease: Cardiomyopathy, Dilated, 1d; Cardiomyopathy, Familial Hypertrophic, 2; Cardiomyopathy, Familial Restrictive, 3
Reference #:  P45379 (UniProtKB)
Alt. Names/Synonyms: Cardiac muscle troponin T; cardiomyopathy, dilated 1D (autosomal dominant); cardiomyopathy, hypertrophic 2; CMH2; CMPD2; cTnT; MGC3889; RCM3; TNNT2; TnTc; troponin T type 2 (cardiac); troponin T type 2, cardiac; Troponin T, cardiac muscle; troponin T2, cardiac
Gene Symbols: TNNT2
Molecular weight: 35,924 Da
Basal Isoelectric point: 4.94  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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