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MAX a transcription factor. Forms a DNA- binding protein complex with MYC or MAD. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor. CPG methylation of the recognition site greatly inhibits DNA binding, suggesting that DNA methylation may regulate the MYC/MAX complex in vivo. May repress transcription via the recruitment of a chromatin remodeling complex containing H3-K9 histone methyltransferase activity. Three alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 14q23.3
Cellular Component: nucleoplasm; nucleus
Molecular Function: DNA binding; protein binding; protein homodimerization activity; transcription coactivator activity; transcription cofactor activity; transcription factor activity
Biological Process: G1/S transition of mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter
Reference #:  P61244 (UniProtKB)
Alt. Names/Synonyms: BHLHD4; bHLHd5; bHLHd6; bHLHd7; bHLHd8; Class D basic helix-loop-helix protein 4; helix-loop-helix zipper protein; MAX; MGC10775; MGC11225; MGC18164; MGC34679; MGC36767; MYC associated factor X; Myc-associated factor X; orf1; Protein max
Gene Symbols: MAX
Molecular weight: 18,275 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
CST Pathways:  Regulation of P38 MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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