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ARHGEF2 a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases. Mediates cross-talk between microtubules and the actin cytoskeleton. Contains a phorbol esters/diacylglycerol binding and PH domain. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1q22
Cellular Component: cytoplasm; cytoskeleton; cytosol; focal adhesion; microtubule; protein complex; vesicle
Molecular Function: guanyl-nucleotide exchange factor activity; microtubule binding; protein binding; Rac GTPase binding; Rac guanyl-nucleotide exchange factor activity; Rho GTPase binding; Rho guanyl-nucleotide exchange factor activity; transcription factor binding
Biological Process: actin filament organization; activation of NF-kappaB transcription factor; cell morphogenesis; negative regulation of microtubule depolymerization; positive regulation of apoptosis; positive regulation of interleukin-6 production; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; regulation of cell proliferation; regulation of small GTPase mediated signal transduction
Disease: Neurodevelopmental Disorder With Midbrain And Hindbrain Malformations
Reference #:  Q92974 (UniProtKB)
Alt. Names/Synonyms: ARHG2; ARHGEF2; DKFZp547L106; DKFZp547P1516; FLJ45440; GEF; GEF-H1; GEFH1; Guanine nucleotide exchange factor H1; KIAA0651; LFP40; Microtubule-regulated Rho-GEF; P40; Proliferating cell nucleolar antigen p40; Rho guanine nucleotide exchange factor 2; Rho/Rac guanine nucleotide exchange factor (GEF) 2; Rho/Rac guanine nucleotide exchange factor 2; RhoGEF2
Gene Symbols: ARHGEF2
Molecular weight: 111,543 Da
Basal Isoelectric point: 6.89  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Microtubule Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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