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ARHGAP5 a GTPase activating protein for Rho family members. May play a role in the reduction of the p21rasGTPase-activating potential of p120GAP. Negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 14q12
Cellular Component: cytoplasm; cytosol; endoplasmic reticulum
Molecular Function: GTPase activator activity; protein binding; SH2 domain binding
Biological Process: cell adhesion; regulation of small GTPase mediated signal transduction; Rho protein signal transduction
Reference #:  Q13017 (UniProtKB)
Alt. Names/Synonyms: ARHGAP5; GFI2; growth factor independent 2; p100 RasGAP-associated p105 protein; p105 RhoGAP; p190-B; p190BRhoGAP; RHG05; Rho GTPase activating protein 5; Rho GTPase-activating protein 5; Rho-type GTPase-activating protein 5; RHOGAP5
Gene Symbols: ARHGAP5
Molecular weight: 172,460 Da
Basal Isoelectric point: 6.18  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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