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EIF4H eukaryotic translation initiation factor 4H stimulates protein translation. May stimulate the activities of EIF4A, EIF4B and EIF4F during the steps involving mRNA binding and utilization in the initiation of protein biosynthesis. Binds mRNA. Two alternatively spliced isoforms have been described. The short isoform is the predominant isoform and is expressed alone in liver and skeletal muscle. Both isoforms are expressed in fibroblast, spleen, testis and bone marrow. Levels are high in lung and pancreas and low in heart, frontal cortex and kidney. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Translation; Translation initiation
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component: cytosol; eukaryotic translation initiation factor 4F complex; membrane; polysome
Molecular Function: cadherin binding; helicase activity; protein binding; ribosomal small subunit binding; RNA binding; RNA strand annealing activity; RNA strand-exchange activity; translation factor activity, nucleic acid binding; translation initiation factor activity
Biological Process: formation of translation preinitiation complex; regulation of translational initiation; translational initiation
Disease: Williams-beuren Syndrome
Reference #:  Q15056 (UniProtKB)
Alt. Names/Synonyms: eIF-4H; EIF4H; Eukaryotic translation initiation factor 4H; IF4H; KIAA0038; WBSCR1; Williams-Beuren syndrome chromosomal region 1 protein; Williams-Beuren syndrome chromosome region 1; WSCR1
Gene Symbols: EIF4H
Molecular weight: 27,385 Da
Basal Isoelectric point: 6.67  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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