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EB1 a microtubule-associated protein of the RP/EB family. Binds to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. Localizes to microtubules, especially the growing ends, in interphase cells. Associates with the centrosomes and spindle microtubules during mitosis. Also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. May be involved in the regulation of microtubule structures and chromosome stability. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 20q11.21
Cellular Component: centrosome; cortical microtubule cytoskeleton; cytosol; microtubule; spindle
Molecular Function: cadherin binding; identical protein binding; microtubule plus-end binding; protein binding; protein C-terminus binding; RNA binding
Biological Process: cell proliferation; G2/M transition of mitotic cell cycle; negative regulation of microtubule polymerization; positive regulation of cell migration; sister chromatid cohesion
Reference #:  Q15691 (UniProtKB)
Alt. Names/Synonyms: adenomatous polyposis coli-binding protein EB1; APC-binding protein EB1; EB1; End-binding protein 1; MAPRE1; MARE1; MGC117374; MGC129946; Microtubule-associated protein RP/EB family member 1; microtubule-associated protein, RP/EB family, member 1
Gene Symbols: MAPRE1
Molecular weight: 29,999 Da
Basal Isoelectric point: 5.02  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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