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VCP an ATPase enzyme present in all eukaryotes and archaebacteria that functions involved in vesicle transport and fusion, and 26S proteasomal degradation. Functions to extract protein molecules from large protein assemblies, membranes and chromatin, facilitating the proteasomal degradation of the extracted proteins by the proteasome. Involved in: the fragmentation of Golgi stacks during mitosis, and for their reassembly after mitosis; the formation of the transitional endoplasmic reticulum (tER); spindle disassembly at the end of mitosis; and the formation of a closed nuclear envelope. Involved in endoplasmic reticulum stress-induced preemptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. Regulates NFKappaB pathway, which is important for metastasis of osteosarcoma. Acts as a negative regulator of type I interferon production by interacting with DDX58: interaction takes place when DDX58 is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of DDX58. Tyrosine phosphorylation regulates its cell cycle-dependent nuclear localization. Note: This description may include information from UniProtKB.
Protein type: Chaperone; DNA repair, damage; EC; Endoplasmic reticulum; Hydrolase
Chromosomal Location of Human Ortholog: 9p13.3
Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; extracellular region; intracellular membrane-bound organelle; lipid particle; nucleoplasm; nucleus; perinuclear region of cytoplasm; proteasome complex; protein complex
Molecular Function: ATPase activity; identical protein binding; polyubiquitin binding; protein binding; protein domain specific binding; protein phosphatase binding; RNA binding; ubiquitin protein ligase binding
Biological Process: autophagy; bypass DNA synthesis; caspase activation; double-strand break repair; endosome to lysosome transport via multivesicular body sorting pathway; ER-associated protein catabolic process; establishment of protein localization; macroautophagy; NADH metabolic process; neutrophil degranulation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein catabolic process; positive regulation of protein complex assembly; proteasomal protein catabolic process; proteasomal ubiquitin-dependent protein catabolic process; protein amino acid methylation; protein amino acid N-linked glycosylation via asparagine; protein deubiquitination; protein folding; protein ubiquitination; regulation of apoptosis; response to DNA damage stimulus; retrograde protein transport, ER to cytosol; transmembrane transport; unfolded protein response; viral genome replication
Disease: Amyotrophic Lateral Sclerosis 14, With Or Without Frontotemporal Dementia; Charcot-marie-tooth Disease, Axonal, Type 2y; Inclusion Body Myopathy With Early-onset Paget Disease With Or Without Frontotemporal Dementia 1
Reference #:  P55072 (UniProtKB)
Alt. Names/Synonyms: 15S Mg(2+)-ATPase p97 subunit; IBMPFD; MGC131997; MGC148092; MGC8560; p97; TER ATPase; TERA; Transitional endoplasmic reticulum ATPase; Valosin-containing protein; VCP; yeast Cdc48p homolog
Gene Symbols: VCP
Molecular weight: 89,322 Da
Basal Isoelectric point: 5.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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