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Protein Page:

NCK1 adapter protein containing Src homology 2 and 3 (SH2 and SH3) domains. Transduces signals from tyrosine-phosphorylated growth factor receptors to their cellular substrates. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3q22.3
Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; intercellular junction; nucleus; plasma membrane; protein phosphatase type 1 complex; ribosome; vesicle membrane
Molecular Function: cadherin binding; cytoskeletal adaptor activity; ephrin receptor binding; protein binding; protein binding, bridging; protein domain specific binding; protein kinase inhibitor activity; receptor binding; receptor signaling complex scaffold activity; receptor tyrosine kinase binding; SH3/SH2 adaptor activity
Biological Process: actin filament organization; ephrin receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; lamellipodium assembly; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation; negative regulation of peptidyl-serine phosphorylation; negative regulation of PERK-mediated unfolded protein response; negative regulation of protein kinase activity; negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; peptidyl-serine dephosphorylation; positive regulation of actin filament polymerization; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; positive regulation of neuron projection development; positive regulation of T cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of translation in response to endoplasmic reticulum stress; regulation of cell migration; response to other organism; signal complex assembly; substrate-dependent cell migration, cell extension; T cell activation; T cell receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway
Reference #:  P16333 (UniProtKB)
Alt. Names/Synonyms: Cytoplasmic protein NCK1; melanoma NCK protein; MGC12668; NCK; NCK adaptor protein 1; NCK tyrosine kinase; Nck-1; NCK1; NCKalpha; non-catalytic region of tyrosine kinase; SH2/SH3 adaptor protein NCK-alpha
Gene Symbols: NCK1
Molecular weight: 42,864 Da
Basal Isoelectric point: 6.06  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  ErbB/HER Signaling  |  Insulin Receptor Signaling  |  T Cell Receptor Signaling  |  Translation: eIF2  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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