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GRF-1 the human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. May participate in the regulation of retinal development and degeneration. May transduce signals from p21-ras to the nucleus, acting via the ras GTP-ase activating protein (GAP). May also act as a tumor suppressor. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis; Transcription factor; Tumor suppressor
Chromosomal Location of Human Ortholog: 19q13.32
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: DNA binding; GTPase activator activity; phospholipid binding; transcription corepressor activity
Biological Process: axon guidance; axonal fasciculation; cell migration; cellular response to extracellular stimulus; central nervous system neuron axonogenesis; establishment and/or maintenance of actin cytoskeleton polarity; mammary gland development; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of flagellum biogenesis; regulation of actin cytoskeleton organization and biogenesis; regulation of actin polymerization and/or depolymerization; regulation of axonogenesis; regulation of small GTPase mediated signal transduction
Reference #:  Q9NRY4 (UniProtKB)
Alt. Names/Synonyms: ARHGAP35; glucocorticoid receptor DNA binding factor 1; Glucocorticoid receptor DNA-binding factor 1; Glucocorticoid receptor repression factor 1; GRF-1; GRF1; GRLF1; KIAA1722; MGC10745; p190-A; P190A; p190ARhoGAP; p190RhoGAP; Rho GAP p190A
Gene Symbols: ARHGAP35
Molecular weight: 170,514 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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