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ARRB2 a member of the arrestin/beta-arrestin protein family. These proteins participate in agonist-mediated desensitization of G-protein-coupled receptors. Acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Expressed at high levels in the CNS and peripheral blood leukocytes. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 17p13.2
Cellular Component: cytoplasm; cytoplasmic vesicle; cytosol; endocytic vesicle; intracellular membrane-bound organelle; nucleus; plasma membrane
Molecular Function: angiotensin receptor binding; enzyme binding; G-protein-coupled receptor binding; protein binding; protein complex scaffold; receptor binding; ubiquitin protein ligase binding
Biological Process: arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway; G-protein coupled receptor internalization; inhibition of NF-kappaB transcription factor; negative regulation of natural killer cell mediated cytotoxicity; negative regulation of protein ubiquitination; platelet activation; positive regulation of protein ubiquitination; positive regulation of receptor internalization; proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; protein ubiquitination; receptor internalization; transcription from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway
Reference #:  P32121 (UniProtKB)
Alt. Names/Synonyms: ARB2; ARR2; ARRB2; arrestin 3; Arrestin beta-2; arrestin, beta 2; BARR2; Beta-arrestin-2; DKFZp686L0365
Gene Symbols: ARRB2
Molecular weight: 46,106 Da
Basal Isoelectric point: 7.59  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Hedgehog Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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