the transferrin receptor. Regulates the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied receptors into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Membrane protein, integral; Receptor, misc.
Cellular Component: basolateral plasma membrane; cell surface; clathrin coated vesicle membrane; coated pit; cytoplasmic vesicle; endosome; endosome membrane; external side of plasma membrane; extracellular region; extracellular space; integral to plasma membrane; perinuclear region of cytoplasm; plasma membrane; recycling endosome
Molecular Function: double-stranded RNA binding; glycoprotein binding; identical protein binding; protein binding; protein homodimerization activity; RNA binding; transferrin receptor activity; transferrin transmembrane transporter activity
Biological Process: positive regulation of B cell proliferation; positive regulation of isotype switching; positive regulation of T cell proliferation; receptor internalization; regulation of cell growth; regulation of cell proliferation; transferrin transport