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TfR the transferrin receptor. Regulates the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied receptors into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 3q29
Cellular Component: basolateral plasma membrane; cell surface; clathrin coated vesicle membrane; coated pit; cytoplasmic vesicle; endosome; endosome membrane; external side of plasma membrane; extracellular region; extracellular space; integral to plasma membrane; perinuclear region of cytoplasm; plasma membrane; recycling endosome
Molecular Function: double-stranded RNA binding; glycoprotein binding; identical protein binding; protein binding; protein homodimerization activity; RNA binding; transferrin receptor activity; transferrin transmembrane transporter activity
Biological Process: positive regulation of B cell proliferation; positive regulation of isotype switching; positive regulation of T cell proliferation; receptor internalization; regulation of cell growth; regulation of cell proliferation; transferrin transport
Disease: Immunodeficiency 46
Reference #:  P02786 (UniProtKB)
Alt. Names/Synonyms: CD71; p90; sTfR; T9; TfR; TfR1; TFRC; transferrin receptor (p90, CD71); Transferrin receptor protein 1; Transferrin receptor protein 1, serum form; Trfr
Gene Symbols: TFRC
Molecular weight: 84,871 Da
Basal Isoelectric point: 6.18  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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