Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

TNFRSF11A Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells. Binds to the clefts between the subunits of the TNFSF11 ligand trimer to form a heterohexamer. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts (via cytoplasmic domain) with GAB2. Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 18q21.33
Cellular Component: cytosol; external side of plasma membrane; integral component of plasma membrane; plasma membrane
Molecular Function: cytokine binding; metal ion binding; protein binding; receptor activity; transmembrane receptor activity; tumor necrosis factor-activated receptor activity
Biological Process: adaptive immune response; cell-cell signaling; circadian temperature homeostasis; inflammatory response; lymph node development; monocyte chemotaxis; ossification; osteoclast differentiation; positive regulation of cell proliferation; positive regulation of JUN kinase activity; positive regulation of NF-kappaB transcription factor activity; positive regulation of transcription factor activity; regulation of apoptosis; response to cytokine; response to lipopolysaccharide; response to radiation; signal transduction; tumor necrosis factor-mediated signaling pathway
Disease: Familial Expansile Osteolysis; Osteopetrosis, Autosomal Recessive 7; Paget Disease Of Bone
Reference #:  Q9Y6Q6 (UniProtKB)
Alt. Names/Synonyms: CD265; FEO; LOH18CR1; loss of heterozygosity, 18, chromosomal region 1; ODFR; OFE; OPTB7; Osteoclast differentiation factor receptor; OSTS; PDB2; RANK; Receptor activator of NF-KB; receptor activator of nuclear factor-kappa B; TNFRSF11A; TNR11; TRANCER; Tumor necrosis factor receptor superfamily member 11A; tumor necrosis factor receptor superfamily, member 11a, activator of NFKB; tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Gene Symbols: TNFRSF11A
Molecular weight: 66,034 Da
Basal Isoelectric point: 5.21  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB