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Protein Page:

TFAM regulates mitochondrial transcription. Induced in humans by caloric restriction. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Activates transcription by binding immediately upstream of transcriptional start sites. Is able to unwind and bend DNA. Involved in cisplatin resistance. Interacts with TFB1M and TFB2M. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription regulation
Chromosomal Location of Human Ortholog: 10q21.1
Cellular Component: cytosol; mitochondrial matrix; mitochondrion; nucleus
Molecular Function: chromatin binding; DNA bending activity; protein binding; RNA binding; transcription factor activity
Biological Process: DNA-dependent DNA replication; mitochondrion organization and biogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase I promoter; transcription from mitochondrial promoter; transcription initiation from mitochondrial promoter
Disease: Mitochondrial Dna Depletion Syndrome 15 (hepatocerebral Type)
Reference #:  Q00059 (UniProtKB)
Alt. Names/Synonyms: Mitochondrial transcription factor 1; mitochondrial transcription factor A; MtTF1; mtTFA; TCF-6; TCF6; TCF6L1; TCF6L2; TCF6L3; TFAM; Transcription factor 6; Transcription factor 6-like 2; Transcription factor 6-like 2 (mitochondrial transcription factor); Transcription factor A, mitochondrial
Gene Symbols: TFAM
Molecular weight: 29,097 Da
Basal Isoelectric point: 9.74  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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