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PRDX1 a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). May have a proliferative effect and play a role in cancer development or progression. Note: This description may include information from UniProtKB.
Protein type: EC; Nuclear receptor co-regulator; Oxidoreductase
Chromosomal Location of Human Ortholog: 1p34.1
Cellular Component: cytoplasm; cytosol; extracellular matrix; extracellular space; nucleus
Molecular Function: cadherin binding; peroxidase activity; protein binding; RNA binding; thioredoxin peroxidase activity
Biological Process: hydrogen peroxide catabolic process; natural killer cell activation; retinal homeostasis; skeletal development
Reference #:  Q06830 (UniProtKB)
Alt. Names/Synonyms: MSP23; Natural killer cell-enhancing factor A; natural killer-enhancing factor A; NKEF-A; NKEFA; PAG; PAGA; PAGB; peroxiredoxin 1; Peroxiredoxin-1; PRDX1; proliferation-associated gene A; Proliferation-associated gene protein; PRX1; PRXI; TDPX2; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2
Gene Symbols: PRDX1
Molecular weight: 22,110 Da
Basal Isoelectric point: 8.27  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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