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Protein Page:
CD276

Overview
CD276 May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. Belongs to the immunoglobulin superfamily. BTN/MOG family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 15q24.1
Cellular Component: external side of plasma membrane; integral component of membrane
Molecular Function: protein binding; receptor binding
Biological Process: cell proliferation; immune response; positive regulation of interferon-gamma biosynthetic process; positive regulation of T cell proliferation; regulation of immune response; T cell activation
Reference #:  Q5ZPR3 (UniProtKB)
Alt. Names/Synonyms: 4Ig-B7-H3; B7 homolog 3; B7-H3; B7H3; CD276; CD276 antigen; CD276 molecule; Costimulatory molecule
Gene Symbols: CD276
Molecular weight: 57,235 Da
Basal Isoelectric point: 4.77  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CD276

Protein Structure Not Found.
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