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ASF1A Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. Interacts with histone H3 (including both histone H3.1 and H3.3) and histone H4. Interacts with the CHAF1A, CHAF1B and RBBP4 subunits of the CAF-1 complex. Interacts with CABIN1, HAT1, HIRA, NASP, TAF1, TLK1, TLK2 and UBN1. Ubiquitously expressed. Belongs to the ASF1 family. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; Histone-binding
Chromosomal Location of Human Ortholog: 6q22.31
Cellular Component: nuclear chromatin; nucleoplasm; nucleus; protein complex
Molecular Function: histone binding; protein binding
Biological Process: DNA repair; DNA replication-dependent nucleosome assembly; DNA replication-independent nucleosome assembly; nucleosome assembly
Reference #:  Q9Y294 (UniProtKB)
Alt. Names/Synonyms: anti-silencing function 1A; Anti-silencing function protein 1 homolog A; ASF1 anti-silencing function 1 homolog A (S. cerevisiae); ASF1A; CCG1-interacting factor A; CGI-98; CIA; DKFZp547E2110; hAsf1; hAsf1a; hCIA; Histone chaperone ASF1A; HSPC146
Gene Symbols: ASF1A
Molecular weight: 22,969 Da
Basal Isoelectric point: 4.29  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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