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CD3E a T cell surface glycoprotein that is a component of the T cell antigen receptor. The recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. Contains 1 immunoglobulin-like domain and 1 ITAM domain. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: alpha-beta T cell receptor complex; cell body; dendritic spine; external side of plasma membrane; immunological synapse; integral component of plasma membrane; intercellular junction; plasma membrane; T cell receptor complex
Molecular Function: protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; receptor signaling complex scaffold activity; receptor signaling protein activity; SH3 domain binding; T cell receptor binding; transmembrane receptor activity
Biological Process: adaptive immune response; cell surface receptor signaling pathway; cerebellum development; dendrite development; G-protein coupled receptor signaling pathway; negative regulation of gene expression; negative regulation of smoothened signaling pathway; negative thymic T cell selection; positive regulation of alpha-beta T cell proliferation; positive regulation of calcium-mediated signaling; positive regulation of gene expression; positive regulation of interferon-gamma production; positive regulation of interleukin-2 biosynthetic process; positive regulation of interleukin-4 production; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of T cell anergy; positive regulation of T cell proliferation; protein complex assembly; protein homooligomerization; regulation of apoptosis; regulation of immune response; response to nutrient; signal complex assembly; T cell activation; T cell costimulation; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway
Disease: Immunodeficiency 18
Reference #:  P07766 (UniProtKB)
Alt. Names/Synonyms: CD3-epsilon; CD3E; CD3E antigen, epsilon polypeptide; CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule, epsilon (CD3-TCR complex); CD3epsilon; FLJ18683; T-cell antigen receptor complex, epsilon subunit of T3; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chain; T3E; TCRE
Gene Symbols: CD3E
Molecular weight: 23,147 Da
Basal Isoelectric point: 6.32  Predict pI for various phosphorylation states
CST Pathways:  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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