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SHIP an SH2-containing inositol phosphatase. A hemopoietic-specific phosphatase that regulates cell survival, growth, cell cycle arrest and apoptosis. Hydrolyzes Ins(1,3,4,5)P4 and PtdIns(3,4,5)P3. A cytosolic protein with a SH2 domain in its N-terminus and two NPXY Shc binding motifs at its C-terminus. Upon receptor cross-linking, SHIP is first recruited to the plasma membrane by its SH2, followed by tyrosine phosphorylation on the NPXY motif. Both membrane relocalization and phosphorylation are essential for its regulatory function. Associates with SHC after cytokine stimulation. Note: This description may include information from UniProtKB.
Protein type: EC; Motility/polarity/chemotaxis; Phosphatase, lipid
Chromosomal Location of Human Ortholog: 2q37.1
Cellular Component: cytosol
Molecular Function: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; protein binding
Biological Process: inositol phosphate metabolic process; leukocyte migration; phosphate metabolic process; phosphatidylinositol biosynthetic process; signal transduction; T cell receptor signaling pathway
Reference #:  Q92835 (UniProtKB)
Alt. Names/Synonyms: hp51CN; Inositol polyphosphate-5-phosphatase of 145 kDa; inositol polyphosphate-5-phosphatase, 145kDa; INPP5D; MGC104855; MGC142140; MGC142142; p150Ship; Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1; SH2 containing inositol phosphatase, isoform b; SH2 domain-containing inositol phosphatase 1; SH2 domain-containing inositol-5'-phosphatase 1; SHIP; SHIP-1; SHIP1; signaling inositol polyphosphate 5 phosphatase SIP-145; SIP-145
Gene Symbols: INPP5D
Molecular weight: 133,292 Da
Basal Isoelectric point: 7.38  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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