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NFAT2 a transcription factor that plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4. Also control gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of lymphoid and nonlymphoid cells. Six splice variant isoforms have been identified. Expressed in thymus, peripheral leukocytes as T-cells and spleen. Isoforms A are preferentially expressed in effector T-cells (thymus and peripheral leukocytes) whereas isoforms B and isoforms C are preferentially expressed in naive T-cells (spleen). Isoforms B are expressed in naive T-cells after first antigen exposure and isoforms A are expressed in effector T-cells after second antigen exposure. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 18q23
Cellular Component: cytoplasm; cytosol; nuclear body; nuclear chromatin; nucleoplasm; nucleus
Molecular Function: FK506 binding; mitogen-activated protein kinase p38 binding; protein binding; RNA polymerase II transcription factor activity, enhancer binding; transcription factor activity
Biological Process: calcineurin-NFAT signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter; Wnt receptor signaling pathway, calcium modulating pathway
Reference #:  O95644 (UniProtKB)
Alt. Names/Synonyms: MGC138448; NF-ATc; NF-ATc1; NFAC1; NFAT transcription complex cytosolic component; NFAT2; NFATC; NFATC1; Nuclear factor of activated T-cells, cytoplasmic 1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
Gene Symbols: NFATC1
Molecular weight: 101,243 Da
Basal Isoelectric point: 6.52  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling
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