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NFAT3 a transcription factor that plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4. Also control gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of lymphoid and nonlymphoid cells. Highly expressed in placenta, lung, kidney, testis and ovary. Weakly expressed in spleen and thymus. Not expressed in peripheral blood lymphocytes. 23 alternatively spliced isoforms of the human protein hve been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 14q12
Cellular Component: cytosol; nuclear speck; nucleus
Molecular Function: protein binding; transcription coactivator activity
Biological Process: inflammatory response; transcription from RNA polymerase II promoter
Reference #:  Q14934 (UniProtKB)
Alt. Names/Synonyms: NF-AT3; NF-ATc4; NFAC4; NFAT3; NFATC4; Nuclear factor of activated T-cells, cytoplasmic 4; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4; T cell transcription factor NFAT3; T-cell transcription factor NFAT3
Gene Symbols: NFATC4
Molecular weight: 95,449 Da
Basal Isoelectric point: 5.29  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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