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Protein Page:

NFAT4 a transcription factor that plays a role in the inducible expression of cytokine genes in T cells. Plays a role in the regulation of gene expression in T cells and immature thymocytes. Six spliced isoforms have been identified. Isoform 1 is predominantly expressed in thymus, peripheral blood leukocytes and kidney. Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen, prostate, ovary, small intestine, heart, placenta and pancreas. Isoform 3 is expressed in thymus and kidney. Isoform 4 is expressed in thymus and skeletal muscle. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: protein binding
Biological Process: inflammatory response; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter
Reference #:  Q12968 (UniProtKB)
Alt. Names/Synonyms: NF-AT4; NF-ATc3; NFAC3; NFAT4; NFATC3; NFATx; nuclear factor of activated T-cells c3 isoform IE-Xa; Nuclear factor of activated T-cells, cytoplasmic 3; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3; T cell transcription factor NFAT4; T-cell transcription factor NFAT4
Gene Symbols: NFATC3
Molecular weight: 115,594 Da
Basal Isoelectric point: 5.91  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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