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VAV2 a proto-oncogenic guanine nucleotide exchange factors (GEF) of the Dbl family. A GEF for the Rho family of GTP binding proteins. Expressed in most tissues. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 9q34.2
Cellular Component: cytosol
Molecular Function: guanyl-nucleotide exchange factor activity; phosphotyrosine binding; protein binding; Rho guanyl-nucleotide exchange factor activity
Biological Process: ephrin receptor signaling pathway; platelet activation; positive regulation of apoptosis; regulation of blood coagulation; regulation of cell size; regulation of gene expression; regulation of GTPase activity; regulation of small GTPase mediated signal transduction; signal transduction; vascular endothelial growth factor receptor signaling pathway
Reference #:  P52735 (UniProtKB)
Alt. Names/Synonyms: Guanine nucleotide exchange factor VAV2; oncogene VAV2; Protein vav-2; vav 2 guanine nucleotide exchange factor; vav 2 oncogene; VAV-2; VAV2
Gene Symbols: VAV2
Molecular weight: 101,289 Da
Basal Isoelectric point: 6.67  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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