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YAP1 an adaptor protein that binds to HER4 and the SH3 domain of the Yes tyrosine kinase. Associates with multiple transcription factors in the nucleus, and appears to be a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus. Contains a WW domain that is found in various structural, regulatory and signaling molecules. Note: This description may include information from UniProtKB.
Protein type: Oncoprotein; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 11q22.1
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: protein binding; protein heterodimerization activity; transcription activator binding; transcription coactivator activity; transcription corepressor activity
Biological Process: cell proliferation; positive regulation of transcription, DNA-dependent; protein complex assembly; regulation of neurogenesis; response to DNA damage stimulus; transcription initiation from RNA polymerase II promoter
Disease: Coloboma, Ocular, With Or Without Hearing Impairment, Cleft Lip/palate, And/or Mental Retardation
Reference #:  P46937 (UniProtKB)
Alt. Names/Synonyms: 65 kDa Yes-associated protein; YAP; YAP1; YAP2; YAP65; Yes-associated protein 1; Yes-associated protein 1, 65kDa; yes-associated protein 2; YKI; Yorkie homolog
Gene Symbols: YAP1
Molecular weight: 54,462 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
CST Pathways:  Hippo Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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